Publications - YONG-XIN LI'S LAB

YONG-XIN LI'S LAB

Selected Publications

12. Cheng, Z; He, BB.; Lei, K.Gao, Y.; Shi, YQ.; Zhong, Z.;Liu, HY.; Liu, RZ.;Zhang, H; Wu, S., Zhang, W.^* Tang, XY.^*;Li, Y.X.^*(2023).Biosynthesis- and Metabolomics-guided discovery of antimicrobial cyclopeptides against drug-resistant clinical isolates. (Preprint)

11. Older, E. A.^#; Zhang, J.^#; Ferris, Z. E.; Xue, D.; Zhong, Z.; Mitchell, M. K.; Michael, M.; Wang, Y.; Chen, H.; Nagarkatti, P.; Nagarkatti, M.; Fan, D.; Ellermann, M.; LI, Y.X.^* Li, J.^* (2023). Human Gut Microbial Sulfonolipids are linked to Inflammatory Bowel Diseases through Toll-Like Receptor 4 Signaling. (In Revision).

10. Cai, PY; He, JZ.; Song, ZM.; Tian, YQ.; Zhong, Z.;Zhang, DW.; Shi, YQ.;Tang, XY.;LI, Y.X.^* (2023). Uncovering Untapped Carboxylic Acid Reductases (CARs) for One-Step Biosynthesis and Diversification of Bioactive Nitrogen-containing Heterocycles. ACS Catalysis. 13, XXX, 15404–15416.

9. He BB^#;Liu J^#; Cheng, Z.;Liu, R.; Zhong, Z.; Gao Y.; Liu, H.;Song,Z.M.; LI, Y.X.^* (2023). Bacterial Cytochrome P450 Catalyzed Post-translational Macrocyclization of Ribosomal Peptides Angewandte Chemie International Edition. e202311533. Hot Paper!

8. Ding, W., Wang, S., Qin, P., Fan, S., Su, X., Cai, P.,... LI, Y.X.^* Zhang, W.^* (2023). Anaerobic thiosulfate oxidation by the Roseobacter group is prevalent in marine biofilms. Nature Communications , 14(1), 2033.(Editors' Highlights in Microbiology and infectious diseases)

7. Dengwei Zhang, Jian Zhang, Shanthini Kalimuthu, Jing Liu, Zhiman Song, Beibei He, Peiyan Cai, Zheng Zhong, Chenchen Feng, Prasanna Neelakantan, Yong-Xin Li^* (2023). A systematic investigation of lactic acid bacteria-derived biosynthetic gene clusters reveals diverse antagonistic bacteriocins in the human microbiome. Microbiome, 11: 91.

6. Haoyu Liang^#, Zhiman Song^#, Zheng Zhong, Dengwei Zhang, Wei Yang, Le Zhou, Ethan Older, Jie Li, Huan Wang, Zhirui Zeng^*, Yong-Xin Li^*, (2023). Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea. Microbiome, 11: 74.

5. Bei-bei He, Zhuo Cheng, Zheng Zhong, Ying Gao, Hongyan Liu, Yong-Xin Li^* (2022). Expanded Sequence Space of Radical S-Adenosylmethionine-Dependent Enzymes Involved in Post-translational Macrocyclization. Angewandte Chemie International Edition, e202212447

4. Dan Xue^#, Ethan A. Older^#, Zheng Zhong^#, Zhuo Shang, Nanzhu Chen, Nolan Dittenhauser, Lukuan Hou, Peiyan Cai, Michael D. Walla, Shi-Hui Dong, Xiaoyu Tang, Prakash Nagarkatti, Mitzi Nagarkatti, Yong-Xin Li^*, Jie Li^* (2022). Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nature communications, 13, 1647

Publications before joining HKU:

3. Zhang, W., Ding, W., Li, Y. X., Tam, C., Bougouffa, S., Wang, R., ... & Sun, J. Marine biofilms constitute a bank of hidden microbial diversity and functional potential. Nature communications, 2019, 10(1), 517.

2. Li YX^#, Zhong Z^#, Zhang W, Qian PY. Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining. Nature Communications, 2018,9(1): 3273. (Editor’s Highlights paper in Therapeutics， Recommended by F1000 Prime as ‘the first discovery of an antibiotic from a genomics approach that shows efficacy in treating a systemic infection’).

1. Li YX, Zhong Z, Hou P, Zhang W, Qian PY. Resistance to nonribosomal peptide antibiotics mediated by D-stereospecific peptidases. Nature Chemical Biology, 2018, 14(4), 381-385. (Highlighted by: F1000 Prime, Xinhua News, TVB News, BTV News, AsiaScientist, Science Daily, Science Newsline, EurekAlert, and more than ten local Newspapers of Hong Kong).

Full list of publications