YONG-XIN LI'S LAB
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Selected Publications

12. Cheng, Z; He, BB.; Lei, K.Gao, Y.; Shi, YQ.; Zhong, Z.;Liu, HY.; Liu, RZ.;Zhang, H; Wu, S., Zhang, W.* Tang, XY.*;Li, Y.X.*(2023).Biosynthesis- and Metabolomics-guided discovery of antimicrobial cyclopeptides against drug-resistant clinical isolates. (Preprint)
11. Older, E. A.#; Zhang, J.#; Ferris, Z. E.; Xue, D.; Zhong, Z.; Mitchell, M. K.; Michael, M.; Wang, Y.; Chen, H.; Nagarkatti, P.; Nagarkatti, M.; Fan, D.; Ellermann, M.; LI, Y.X.* Li, J.* (2023). Human Gut Microbial Sulfonolipids are linked to Inflammatory Bowel Diseases through Toll-Like Receptor 4 Signaling. (In Revision).
10. Cai, PY; He, JZ.; Song, ZM.; Tian, YQ.; Zhong, Z.;Zhang, DW.; Shi, YQ.;Tang, XY.;LI, Y.X.* (2023). Uncovering Untapped Carboxylic Acid Reductases (CARs) for One-Step Biosynthesis and Diversification of Bioactive Nitrogen-containing Heterocycles. ACS Catalysis. 13, XXX, 15404–15416.
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9. He BB#;Liu J#; Cheng, Z.;Liu, R.; Zhong, Z.; Gao Y.; Liu, H.;Song,Z.M.; LI, Y.X.* (2023). Bacterial Cytochrome P450 Catalyzed Post-translational Macrocyclization of Ribosomal Peptides Angewandte Chemie International Edition. e202311533. Hot Paper!
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8. Ding, W., Wang, S., Qin, P., Fan, S., Su, X., Cai, P.,... LI, Y.X.* Zhang, W.* (2023). Anaerobic thiosulfate oxidation by the Roseobacter group is prevalent in marine biofilms. Nature Communications , 14(1), 2033.(Editors' Highlights in Microbiology and infectious diseases)
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7. Dengwei Zhang, Jian Zhang, Shanthini Kalimuthu, Jing Liu, Zhiman Song, Beibei He, Peiyan Cai, Zheng Zhong, Chenchen Feng, Prasanna Neelakantan, Yong-Xin Li* (2023). A systematic investigation of lactic acid bacteria-derived biosynthetic gene clusters reveals diverse antagonistic bacteriocins in the human microbiome. Microbiome, 11: 91.

6. Haoyu Liang#, Zhiman Song#, Zheng Zhong, Dengwei Zhang, Wei Yang, Le Zhou, Ethan Older, Jie Li, Huan Wang, Zhirui Zeng*, Yong-Xin Li*, (2023). Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea. Microbiome, 11: 74.

5. Bei-bei He, Zhuo Cheng, Zheng Zhong, Ying Gao, Hongyan Liu, Yong-Xin Li* (2022). Expanded Sequence Space of Radical S-Adenosylmethionine-Dependent Enzymes Involved in Post-translational Macrocyclization. Angewandte Chemie International Edition, e202212447
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4. Dan Xue#, Ethan A. Older#, Zheng Zhong#, Zhuo Shang, Nanzhu Chen, Nolan Dittenhauser, Lukuan Hou, Peiyan Cai, Michael D. Walla, Shi-Hui Dong, Xiaoyu Tang, Prakash Nagarkatti, Mitzi Nagarkatti, Yong-Xin Li*, Jie Li* (2022). Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nature communications, 13, 1647  
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Publications before joining HKU:
3. ​Zhang, W., Ding, W., ​Li, Y. X., Tam, C., Bougouffa, S., Wang, R., ... & Sun, J. Marine biofilms constitute a bank of hidden microbial diversity and functional potential. Nature communications, 2019, 10(1), 517.
2. Li YX#, Zhong Z#, Zhang W, Qian PY. Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining. Nature Communications, 2018,9(1): 3273.  (Editor’s Highlights paper in Therapeutics, Recommended by F1000 Prime as ‘the first discovery of an antibiotic from a genomics approach that shows efficacy in treating a systemic infection’).

1. ​Li YX, Zhong Z, Hou P, Zhang W, Qian PY. Resistance to nonribosomal peptide antibiotics mediated by D-stereospecific peptidases. Nature Chemical Biology, 2018, 14(4), 381-385. (Highlighted by: F1000 Prime, Xinhua News, TVB News, BTV News, AsiaScientist, Science Daily, Science Newsline, EurekAlert, and more than ten local Newspapers of Hong Kong).
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  • Home
  • Research
    • Develop new bioinformatic pipelines for the antibiotic discovery
    • Biosynthesis, bioengineering, and bioactivity of peptide antibiotics
    • Microbe-derived peptides from the human microbiome
  • People
    • Dr. Yong-Xin Li
    • Lab Members
    • Alumni
    • Gallery
  • Publications
  • Join us