About Us
We are a dynamic and passionate team dedicated to discovering innovative therapeutics from complex microbiota. In the face of multi-antibiotic-resistant bacteria, also known as "superbugs," the need for novel drugs to combat antibiotic-resistant pathogens has become more urgent than ever. Fortunately, microbiota provides a rich and largely untapped source of diverse natural products (NPs) such as signal molecules and antibiotics that can be leveraged for drug discovery.
Our laboratory focuses on establishing an integrated platform for targeted antibiotic discovery, using cutting-edge techniques in bioinformatics, synthetic biology, and chemical biology. By unlocking the genetic potential of ocean and human microbiota and characterizing novel biosynthesis pathways, we aim to generate new natural products with the potential to become life-saving therapeutics.
Genomics-guided and Synthetic Biology-enabled Discovery of New Antibiotics
Human Microbiome: Unraveling the Microbial Language in our gut
Latest News
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Oct.16 2024
A huge congratulations to Jian Zhang for her successful thesis defense. Well done, Dr. Zhang!
Oct.5 2024
Our most recent collaborative research on biosynthetic analysis of human microbiome has been accepted by Nature Communications, Congratulations to Jian Zhang for the discovery of TLR4-antagonizing sulfonolipids!
Sep.5 2024
A huge congratulations to Peiyan for her excellent performance in her thesis exam. Well done, Dr. Cai!
Aug. 2024
The group welcomes new PhD students Xiuqi Jiang and Xiaoxuan Chen and Mphil student Jiaqi Liu
Aug. 2024
The group welcomes new Postdoc Dr.Bo Huang and Research Assisant Zhuohan Li
July, 2024
Our latest research on Metabolic Engineering of “Last-line Antibiotic” Colistin has been published in Metabolic Engineering, Big Congrats to Nanzhu!
July, 2024
Nanzhu has won the Outstanding Poster Award by Exploration of Drug Science journal during the 18th Chinese International Peptide Symposium, Congratulations!
May.28 2024
Our latest research on rule-based omics mining of RiPPs antibiotics has been accepted by Nature Communications, Big Congrats to Zhuo Cheng!
Apr.4 2024
Our latest research on metagenome mining of RiPPs has been published in Microbiome, Big Congrats to Gaoying and Zheng Zhong!
Mar.27 2024
A huge congratulations to Nanzhu for his excellent performance in his Mphil thesis exam.
Mar.4 2024
Congratulations to Beibei for his Best Poster Presenter Award in HKU Research Postgraduate Symposium 2024, well done!
Feb. 2024
The group welcomes new UG interm Wingyi and Jinxiang.
Jan.25 2024
A huge congratulations to Beibei for his exceptional performance in his thesis exam. Well done, Dr. He!
Jan.2 2024
The group welcomes new UG interm Denise Dela ADZAKEY.
Dec.1 2023
The group welcomes the new PhD student Xiaoqian Lin.
Oct.28 2023
Our "Drug Discovery from Nature" demo at the university openday attracted hundreds of visitors and served as an inspiration for the younger generation, fostering their interest in the fields of chemical biology and drug discovery.
Oct.24 2023
The group welcomes the new UG interms Leyi Wu and Xiaoyuan LI.
Oct.23 2023
Our latest research on CAR enzymes has been accepted by ACS Catalysis, Congrats to Peiyan! Oct.18 2023
Zheng Zhong, our first PhD student, successfully defended his PhD thesis! Congratulations to Zheng Zhong on graduation!!
Sep.28 2023
Our latest research of P450 Catalyzed Post-translational Macrocyclization has been accepted by Angewandte Chemie, Congrats to BeiBei He and Jing Liu! Read here.
Sep. 2023
The group welcomes the new members Dr. Junliang Zhang and Cunlei Cai.
July. 2023
Congrats to BeiBei for winning the Best Oral Presentation Award in 5th Mycology Symposium and 3rd Microbial Pharmaceuticals Academic Conference.
July. 2023
Congrats to BeiBei for winning the HKU Foundation Publication Award.
May. 2023
Our latest research of human microbiome-derived antimicrobials has been published in Microbiome Read here.
April. 2023
Our latest research of Archaea-derived antimicrobials has been published in Microbiome Read here.
Mar. 2023
Our latest collaborative research on marine biofilms has been published in Nature Communication Read here.
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