We are an enthusiastic team focusing on antibiotic discovery from complex microbiota. The emergence of multi-antibiotic-resistant bacteria known as "superbugs" is an increasingly severe threat to global health, highlighting the urgent need for new drugs to kill antibiotic-resistant pathogens. Microbiota produces diverse natural products (NPs), such as signal molecules and antibiotics that mediate communication and competition in the environment and human body, which are the vast unexplored source for drug discovery. Our lab aims to establish an integrated platform for the targeted discovery of natural product antibiotics by combining bioinformatics, synthetic biology, and chemical biology. Applying our approaches to the ocean and human microbiota, we want to access their untapped genetic potential to generate new natural products and analogs by characterizing and utilizing novel biosynthesis. Additionally, by harnessing the enzymatic potential of NP biosynthesis, we aim to bioengineer new-to-nature analogs with more desirable characteristics, to enhance the reservoir of potentially therapeutic small molecules. We also plan to delve into the chemical ecology of the complex microbiota by studying the chemical "language" of host-microbe interactions.