About Us
We are a dynamic and passionate team dedicated to discovering innovative therapeutics from complex microbiota. In the face of multi-antibiotic-resistant bacteria, also known as "superbugs," the need for novel drugs to combat antibiotic-resistant pathogens has become more urgent than ever. Fortunately, microbiota provides a rich and largely untapped source of diverse natural products (NPs) such as signal molecules and antibiotics that can be leveraged for drug discovery.
Our laboratory focuses on establishing an integrated platform for targeted antibiotic discovery, using cutting-edge techniques in bioinformatics, synthetic biology, and chemical biology. By unlocking the genetic potential of ocean and human microbiota and characterizing novel biosynthesis pathways, we aim to generate new natural products with the potential to become life-saving therapeutics.
In addition, we are passionate about studying the chemical ecology of complex microbiota and the intricate "language" of host-microbe interactions. By gaining a deeper understanding of how microbes communicate and compete with one another in their environments or human microbiome, we hope to identify new targets for drug discovery and develop more effective strategies for maintaining human microbiome homeostasis.
Ultimately, our goal is to harness the power of small molecule biosynthesis to develop new, innovative therapeutics to address one of the most pressing global health challenges of our time. Join us on this exciting mission to make a meaningful impact on the future of healthcare.
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Latest News
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Oct. 2022
The group welcomes the new Postdoc Yongqi Tian.
Oct. 2022
Our latest research has been accepted by Angewandte Chemie. Read here.
Aug. 2022
The group welcomes Runze Liu, Gengfan Wu and Yuqi Shi as our new members!
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