We are a dynamic and passionate team dedicated to discovering innovative therapeutics from complex microbiota. In the face of multi-antibiotic-resistant bacteria, also known as "superbugs," the need for novel drugs to combat antibiotic-resistant pathogens has become more urgent than ever. Fortunately, microbiota provides a rich and largely untapped source of diverse natural products (NPs) such as signal molecules and antibiotics that can be leveraged for drug discovery.
Our laboratory focuses on establishing an integrated platform for targeted antibiotic discovery, using cutting-edge techniques in bioinformatics, synthetic biology, and chemical biology. By unlocking the genetic potential of ocean and human microbiota and characterizing novel biosynthesis pathways, we aim to generate new natural products with the potential to become life-saving therapeutics.
Genomics-guided and Synthetic Biology-enabled Discovery of New Antibiotics
In addition, we are passionate about studying the chemical ecology of complex microbiota and the intricate "language" of host-microbe interactions. By gaining a deeper understanding of how microbes communicate and compete with one another in their environments or human microbiome, we hope to identify new targets for drug discovery and develop more effective strategies for maintaining human microbiome homeostasis.
Ultimately, our goal is to harness the power of small molecule biosynthesis to develop new, innovative therapeutics to address one of the most pressing global health challenges of our time. Join us on this exciting mission to make a meaningful impact on the future of healthcare.
Human Microbiome: Unraveling the Microbial Language in our gut
A huge congratulations to Beibei for his exceptional performance in his thesis exam. Well done, Dr. He!
The group welcomes new UG interm Denise Dela ADZAKEY.
The group welcomes the new PhD student Xiaoqian Lin.
Our "Drug Discovery from Nature" demo at the university openday attracted hundreds of visitors and served as an inspiration for the younger generation, fostering their interest in the fields of chemical biology and drug discovery.
The group welcomes the new UG interms Leyi Wu and Xiaoyuan LI.
Our latest research on CAR enzymes has been accepted by ACS Catalysis, Congrats to Peiyan!Oct.18 2023
Zheng Zhong, our first PhD student, successfully defended his PhD thesis! Congratulations to Zheng Zhong on graduation!!
Our latest research of P450 Catalyzed Post-translational Macrocyclization has been accepted by Angewandte Chemie, Congrats to BeiBei He and Jing Liu! Read here.
The group welcomes the new members Dr. Junliang Zhang and Cunlei Cai.
Congrats to BeiBei for winning the Best Oral Presentation Award in 5th Mycology Symposium and 3rd Microbial Pharmaceuticals Academic Conference.
Congrats to BeiBei for winning the HKU Foundation Publication Award.
Our latest research of human microbiome-derived antimicrobials has been published in Microbiome Read here.
Our latest research of Archaea-derived antimicrobials has been published in Microbiome Read here.
Our latest collaborative research on marine biofilms has been published in Nature Communication Read here.